RESUMEN
Background: The coronavirus disease of 2019 (COVID-19) is a severe public health issue that has infected millions of people. The effective prevention and control of COVID-19 has resulted in a considerable increase in the number of cured cases. However, little research has been done on a complete metabonomic examination of metabolic alterations in COVID-19 patients following treatment. The current project pursues rigorously to characterize the variation of serum metabolites between healthy controls and COVID-19 patients with nucleic acid turning negative via untargeted metabolomics. Methods: The metabolic difference between 20 COVID-19 patients (CT ≥ 35) and 20 healthy controls were investigated utilizing untargeted metabolomics analysis employing High-resolution UHPLC-MS/MS. COVID-19 patients' fundamental clinical indicators, as well as health controls, were also collected. Results: Out of the 714 metabolites identified, 203 still significantly differed between COVID-19 patients and healthy controls, including multiple amino acids, fatty acids, and glycerophospholipids. The clinical indexes including monocytes, lymphocytes, albumin concentration, total bilirubin and direct bilirubin have also differed between our two groups of participators. Conclusion: Our results clearly showed that in COVID-19 patients with nucleic acid turning negative, their metabolism was still dysregulated in amino acid metabolism and lipid metabolism, which could be the mechanism of long-COVID and calls for specific post-treatment care to help COVID-19 patients recover.
RESUMEN
The outbreak of coronavirus disease 2019 (COVID-19) and its worldwide spread has an unprecedented impact on many people's daily life. As an external crisis event that is not going to end any time soon, will COVID-19 affect people's risk judgment towards other risk items in daily life? The present study addresses this gap by examining the effect of the COVID-19 pandemic on judgments of risk and benefit, and further exploring the underlying mechanisms. Three hundred and forty-nine participants were recruited and divided into two groups based on whether they were severely affected or mildly affected by COVID-19. The results showed that the severely affected group (vs. the mildly affected group) gave higher judgments of risk and lower judgments of benefit towards risk items such as "air travel" and "nuclear power plant," and these effects were mediated by the COVID-19-induced negative emotions (fear and anxiety). This study suggests that the adverse effects brought from one external crisis event (e.g., the current COVID-19 pandemic) will spill over and interfere with the judgment of the decision-maker on other routine matters through negative emotions.